Amjad Khan was born on 12 November 1940 in Hyderabad. He was the son of legendary actor Jayant. He was the brother of actor Imtiaz Khan and Inayat Khan. For Amjad theatre was his first love. His first film was as a child artist was at the age of 17 in the film Ab Dilli Dur Nahin (1957). He had assisted K. Asif in the film Love and God in the late 1960s and had also made a brief appearance in the film which would have been his official film debut. But the film was left incomplete after K. Asif's death in 1971 and it ended up releasing in 1986. He worked in over 130 films in his film career spanning nearly twenty years. He enjoyed iconic popularity for his villain roles in Hindi language films — he is most famous for playing the role of the dacoit Gabbar Singh in Sholay (1975).After the success of Sholay Khan continued to play villain roles in films like "The great gambler", "Hum kissise kum nahin","Yaarana", Nasseb and "Qurbani" all of which were hits. Khan was also acclaimed for playing many other unconventional roles in the critically acclaimed film Shatranj Ke Khiladi (1977), directed by Satyajit Ray.In 1976, he had met with a near fatal accident on the Bombay-Goa road, when he drove his car into a tree while trying to avoid a boulder. The drugs administered to him for treatment caused a serious weight problem for the rest of his life.Amjad was also the President of the Actor's GUILD association.
Amjad married Sheila khan in 1972 . He has three children Shadaab Khan, who acted in a few films. He also had a daughter Ahlam Khan and another son Seemaab Khan.Khan passed away in 1992 suffering from a heart failure at the age of 51.