Atul Agnihorti made his maiden appearance as a child in the movie Pasand Apni Apni. He is married to film star Salman Khan's sister, Alvira.
As an adult his debut film was Mahesh Bhatt's Sir (1993). He then acted in some films in the 1990s and early 2000s with his most well known films including Krantiveer (1994), Aatish (1994) and Hum Tumhare Hain Sanam (2002).
He made his directorial debut with the 2004 film, Dil Ne Jise Apna Kahaa which starred his brother-in-law Salman Khan and Preity Zinta in lead roles. In 2007 he started work on his second directorial film Hello, which has a huge cast including his brother-in-law Sohail Khan, Isha Koppikar and Sharman Joshi, did not meet with much commercial success.
He is working as an actor in a film called Roshan which is yet to be released.