By Emmy Iyer(07 May 2011)
E movie revolves around bio-war and its potential dangers and how poor gullible Indians are made victims by International pharmaceutical companies that come to India to uses its people as Guiana Pigs to test their new formulations.
Eswaran (Jeeva) alias E an orphan is a slum dweller in Chennai. He is supported by an old lady. E along with his friend Tony (Karunas) carries out small crimes to earn money. E brought up in tough conditions, grows up as a tough, fearless and emotionless guy.
Jyoti (Nayanthara), a bar dancer from Mumbai comes to Chennai and stays in a house opposite to E's. As days go by, Jyoti learns about E's past. She gets attracted towards E. Meanwhile; Dr.Ramakrishnan (Ashish Vidyarthi) a quack comes to the slum and projects himself as a do-gooder to people living there.
E saves Dr.Ramakrishnan from Nellai Mani (Pasupathy), a terrorist, who is after the Doctor to kill him. Mani tells about Ramakrishna's evil designs. The rest of the movie is about how E foils the doctor's malicious actions and brings him to books.