Golmaal Returns, the sequel to the superhit movie Golmaal Fun Unlimited, traces the misadventures of Gopal (Ajay Devgan) and his wife Ekta (Kareena Kapoor). The couple lives with Gopal's sister Esha (Amrita Arora) and Ekta's mute brother Lucky (Tusshar Kapoor).
One night Gopal saves a young woman named Meera (Celina Jaitley) from a few thugs and as things develop they are forced to wait the night out in a yacht. When Gopal does not show up for the entire night, Ekta, who is obsessed with Ekta Kapoor’s TV soaps, suspects Gopal of having an extra marital affair.
Gopal cooks up a story about spending the night with a fictitious person called Anthony Gonsalves and convinces one of his colleagues Laxman (Shreyas Talpade) to play along.
Madhav (Arshad Warsi), Esha's boyfriend and a headstrong policeman, discovers a dead body from the spot Gopal and Meera took refuge in. He uses the coincidence at which to settle his differences with Gopal and looks at cornering him.