Born in Carmel Valley, California, Metcalfe was raised in Northeastern, Connecticut. He attended the Williams School, a private high school in New London, Connecticut. Metcalfe pursued his higher education at New York University where he studied acting and film at the prestigious Tisch School of the Arts.
Metcalfe first appeared on the small screen in NBC's daytime drama, 'Passions', but rose to fame on the mega-hit series, 'Desperate Housewives' playing teenage boy-toy, John Rowland. He's since been the lead in both studio and independent features. Best known for carrying Twentieth Century Fox's successful teen-comedy "John Tucker Must Die" and starring opposite Michael Douglas in "Beyond A Reasonable Doubt".
2011 saw Jesse cast in TNT's reboot of the iconic series, 'Dallas'. Playing the Christopher Ewing, son of Bobby Ewing (Patrick Duffy).
Metcalfe is an avid art enthusiast and collector, plays both guitar and piano, enjoys basketball, boxing and weight training.