Kaafila is the story of a group of illegal immigrants who are headed towards the developed world. It shows how their journey has many obstacles, danger, and problems. The story covers the countries of India, Russia, Eastern Europe, Afghanistan and Pakistan.
Sunny Deol plays the role of a generous and devout Pakistani, an ISI agent.
The movie also includes the real-life incident of the Malta Boat Tragedy in which more than 300 illegal immigrants perished. There are also references to the Russian mafia, a scientist with plutonium, and the Taliban.