Keshto Mukherjee specialised in comic roles of a drunkard in Hindi films. Keshto made his debut in Ritwik Ghatak’s Bengali movie Nagarik (1952). He was spotted by Hrishikersh Mukherjee who cast him in his debut film Musafir (1957). Keshto always acted in short character roles which often went unnoticed till Asit Sen cast him as a drunkard in Maa Aur Mamta(1970). This movie started a tring of roles as a drunkard and Keshto became synonymous with these roles.
Keshto Mukherjee was a part of some of the greatest movies of his times , He was a permanent fixture in movies made by Hrishikesh Mukherjee, Basu Chatterhee, Gulzar and Mehmood. His big films include China Town (1962), Asli Naqli (1962), Teesri Kasam (1966), Majhli Didi (1967), Sadhu Aur Shaitan (1968), Padosan (1968), Mere Apne (1971), Bombay To Goa (1972), Parichay (1972), Zanjeer (1973), Aap Ki Kasam (1974), Sholay (1975), Chupke Chupke (1975), Gol Maal (1979) and Khubsoorat (1980). His roles of Hariram Nayi in Sholay, James in Chupke Chupke and Ashrafi Lal in Khubsoorat are remembered to this day.
Kesto Mukherjee died in 1985.