Love Story 2050 as the name suggests, is based in the future. The central characters in the story are Karan (Harman Baweja), an adventurous boy who does not believe in sticking to norms and rules. Sana (Priyanka Chopra) on the other hand is a shy and demure girl who is grounded and disciplined. They soon get romantically involved with each other. Life takes a turn when Karan's uncle, Dr. Yatinder Khanna's (Boman Irani) time machine finally works. Sana wishes to travel into the future and the movie is transported into Mumbai in 2050. Sana along with Uncle Yatinder, Rahul and Thea (Sana's younger brother and sister) is now in Mumbai 2050. Needles to say, Mumbai in 2050 is a changed city with flying cars, 200 storey buildings, robots and sky rails et al.
Karan evenually finds himself separating from his love. QT, a friendly girl robot and Boo, a small robotic teddy bear play their distinct roles in bringing their love story together. However, they are soon under the evil threat of Dr. Hoshi, who is in power. It remains to be seen as to whether Karan is able to win back his love, save himself and the family from the clutches of Dr. Hoshi and travel back in time.