Sadhana Bose was born on 20th April 1914. Her father was Saral Sen.
From the college life she was interested in singing and dancing. She learnt singing from Girijashankar and Mihit Bhattacharya. Her debut film was Ali Baba directed by actor director Madhu Bose. She was one of the leading actress of Madhu Bose’s drama troupe, “Calcutta Art Players. In Ali Baba she played the role of Marjina. Right from the first film she became popular. Her acting talent was praised not only by the audience but also by the critics. She married Madhu Bose on 15th December 1930, Madhu and Sadhana was the golden pair of the Bengali Film Industry. She was a very good dancer. She had her own ballet group. She also acted in some Hindi Films. She acted in Avimoni, Kumkum, Rajnartaki, Purbarag, Maa O Chhele in the lead role. Her married life was not happy. She died on 3rd October 1973.