Ryan Bingham (George Clooney), a corporate downsizer and consummate modern business traveler who, after years of staying happily airborne, suddenly finds himself ready to make a real connection.
Ryan has long been contented with his unencumbered lifestyle lived out across America in airports, hotels and rental cars. He can carry all he needs in one wheel-away case; he's a pampered, elite member of every travel loyalty program in existence; and he's close to attaining his lifetime goal of 10 million frequent flier miles - and yet... Ryan has nothing real to hold onto.
When he falls for a simpatico fellow traveler (Vera Farmiga), Ryan's Boss (Jason Bateman), inspired by a young, upstart efficiency expert (Anna Kendrick), threatens to permanetly call him in from the road. Faced with the prospect, at once terrifying and exhilarating, of being grounded, Ryan begins to contemplate what it might actually mean to have a home.